1 Inflammation - induced shift in spinal GABAA signaling is associated with a tyrosine - 1 kinase dependent increase in GABAA current density in nociceptive

4 Author contributions: YZ contributed to the experimental design, all data acquisition and 5 analysis, and preparation of the manuscript. SD contributed to the collection of behavioral data. 6 MG contributed to the experimental design, data analysis and preparation of the manuscript. 7 8 Author affiliation: Dept of Neural and Pain Sciences, University of Maryland, Baltimore School 9 of Dentistry, Baltimore, Maryland and Depts of Anesthesiology, Neurobiology and Medicine 10 (Division of Gastroenterology Hepatology and Nutrition), the Center for Neuroscience at the 11 University of Pittsburgh, and the Pittsburgh Center for Pain Research, University of Pittsburgh, 12 Pittsburgh, USA 13 14 Running Title: Inflammation-induced shift in GABAA signaling 15